Scleroderma overlap syndromes

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'Overlap' syndromes.

Many of us at the end of a weekly lupus clinic are tempted to reflect that almost all shades of connective tissue 'overlap' occur, and that it is perhaps pointless to attempt too precise a definition in individual cases. The introduction of the concept of overlap syndromes was a pragmatic way to resolve an imprecise compromise. It represented an attempt to categorise various groups of disorders...

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Immunolocalization and partial characterization of a nucleolar autoantigen (PM-Scl) associated with polymyositis/scleroderma overlap syndromes.

Precipitating anti-PM-Scl antibodies are present in sera from patients with polymyositis, scleroderma, and polymyositis/scleroderma overlap syndromes. By indirect immunofluorescence microscopy, anti-PM-Scl antibodies stained the nucleolus in cells of different tissues and species, suggesting that the antigen is highly conserved. By electron microscopy, anti-PM-Scl antibodies reacted primarily w...

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Overlap connective tissue syndromes.

Twenty six children with overlapping features of more than one connective tissue disorder are reported. The median age of onset was 9.5 years and median duration of follow up 7.5 years. Common presenting symptoms included arthritis, tenosynovitis. Raynaud's phenomenon, myositis, and rashes. At follow up 14 patients had developed sclerodermatous skin changes, but significant systemic involvement...

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Overlap syndromes with sarcoidosis.

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Bilateral coxitis in scleroderma-polymyositis overlap syndrome.

Joint manifestations in scleroderma (Scl) and polymyositis (PM) are dominated by inflammatory arthralgia. Arthritis is less common and preferentially affects the hands, wrists, knees, and ankles. Involvement of the hip has been rarely reported in the literature. We report a case of coxitis diagnosed in a patient suffering from scleroderma-polymyositis overlap syndrome successfully treated by ul...

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ژورنال

عنوان ژورنال: International Journal of Rheumatic Diseases

سال: 2016

ISSN: 1756-1841

DOI: 10.1111/1756-185x.13011